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Mathematical prerequisites: Students taking this course are expected to have some familiarity with linear algebra, single variable calculus, and differential equations.
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Finally, you will gain insights through seeing real world examples of the possible applications and challenges for the rapidly-growing drone industry. You will be exposed to the challenges of using noisy sensors for localization and maneuvering in complex, three-dimensional environments. 10, R25 (2009).How can we create agile micro aerial vehicles that are able to operate autonomously in cluttered indoor and outdoor environments? You will gain an introduction to the mechanics of flight and the design of quadrotor flying robots and will be able to develop dynamic models, derive controllers, and synthesize planners for operating in three dimensional environments.
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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. K-means clustering via principal component analysis. The spatial organization of centromeric heterochromatin during normal human lymphopoiesis: evidence for ontogenically determined spatial patterns. Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes. Evolution's cauldron: duplication, deletion, and rearrangement in the mouse and human genomes. Kent, W.J., Baertsch, R., Hinrichs, A., Miller, W. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Spatial partitioning of the regulatory landscape of the X-inactivation centre. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Genomics tools for unraveling chromosome architecture. Three-dimensional folding and functional organization principles of the Drosophila genome. Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. Kalhor, R., Tjong, H., Jayathiilaka, N., Alber, N. A three-dimensional model of the yeast genome. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. The eigenvalue tells whether the special vector x is stretched or shrunk or reversed or left unchangedwhen it is multiplied by A. Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Multiply an eigenvector by A, and the vector Ax is a number times the original x. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Impact of chromatin structures on DNA processing for genomic analyses.
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A large genome center's improvements to the Illumina sequencing system. Systematic bias in high-throughput sequencing data and its correction by BEADS.